Цитата:
The D-Ribose from the PPP, is alternative fuel pathway most of “paleo” does not believe exists to fuel performance. Ironically, few paleo’s would argue that predators, like lions, are non performance athletes. Fructose and glucose are not the only way to replenish liver glycogen for explosive exercise or performance. D-ribose restores glycogen levels in the liver of high performance animals who eat a fat laden ketogenic diet very quickly. The D-Ribose substrate is the jet fuel restoration intermediate, that many in the exercise physiology literature have missed in their performance template for diet and it is a vital component of the fat burning pathway in human mitochondria that has three major functions:
Вопрос про экзогенную Д-рибозу
Цитата:
Listening to your 2013 webinar on mitochondrial Rx you mentioned D-Ribose.
As this was recorded back in 2013 when your website was at a different stage, would you still suggest D-Ribose for mito, or was this simply a bridge to the sun?
I only ask because if we are trying to access the PPP which could take 2-3 years, and this is largely due to endogenous upregulation of D-Ribose, would taking it exogenously interfere with that process?
My thoughts are yes.
Ответ Круза:
Цитата:
D-ribose helps......remember that autophagy and apoptosis use carbohydrates as a braking mechanism to take out high heteroplasmy mito and replace them. This is why I go after guys like Jimmy Moore and why I warned Andrew Scarborough in London what he is doing with Dom D'Agastino may no tbe well thought out with a glioma. Ketosis under artificial light devoid of sunlight without marine fatty acids can therefore lead to de-diferentiation of the tumor because tissues cannot clear bad mitochondria as nature inteneded!!!! This is why I am no fan of the LCHF food guru's They never get to this level of sophistication and people with bad circadian diseases are being lead off a cliff!
Food is just a tool, according to Mother Nature!! You have to use this tool correctly within the dictums of photosynthesis and seasonal biology for your location to get things working right in your mitochondria! Our surroundings and our environment give the software program to the mitochondria to run it and food give us the tools/fuel to use with this program!!!!!
https://www.ncbi.nlm.nih.gov/pubmed/12213820
И про холод:
Цитата:
The biggest factor in this ability is the molecular clock. It is easy to explain, once you realize that you can’t access the fat burning pathway when your molecular sense of timing is off.
This is what I laid out in detail in EMF 4.
When you molecular clocks are off you can never benefit from true fat burning because you are burning glucose and fructose neither of which make enough ATP to move electrons in your semiconductors well when your redox potential is low. When your molecular clock is off so is your redox potential in all cell membranes and especially your mitochondria. When this happens you have poor collagen function (no triple helix), poor water structure with no charge separation, poor hormones panels because they are a mirror of how well or poor you move electrons or protons within your semiconductors, and relatively small chance of living chemically reduced within the PPP. It is about electrons and ATP.....not macro's. Fats give you the most electrons............
If you dont you will first get sick and then you die slowly on the vine………..
My take on exercise then becomes simple to understand……once you fix the semiconductor issues in your body even partially……collagen and water begin to react better to stressors……you then can exercise…….why? Any stress, pressure, movement, massage, increases muscle, tendon, and cartilage actions in a semiconductor is to generate a piezoelectric signal (BECKER's KEY POINT)…….A piezoelectric signal can change light to a mechanical signal or an electrical signal to a mechanical one and that changes chemical energy to an electric signal that the brain can translate in its language as an electromagnetic computer (EE6) …….if your semi conductors are limited in holding its charge or broken or severely hampered (Leptin Resistance or high cytokine levels for any reason) then you need to back off exercise and focus on getting your conditions of existence to be able to access the PPP with ease……….to move electrons well to increase your overall redox potential.........FAT DOES THIS BEST. NO ONE NEEDS GLYCOGEN WHEN IT IS A COLD AND KETOTIC WORLD THAT BATHE YOUR SEMICONDUCTORS
The Pentose-phosphate pathway has a wide range of purposes in the cell. It provides a constant supply of NADPH, which is used in biosynthesis. The pathway also produces Ribose-5-phosphate, which is required for nucleic acid synthesis. Also in the Pentose-phosphate pathway two glycolytic intermediates are formed:
1. Fructose-6-phosphate (the PEAT WAY) and
2.Glyceraldehyde-3-phosphate. (THE KRUSE WAY VIA FATS)
Regulation of the Pentose Phosphate Pathway:
Due to the first step of this pathway being reversible, it is highly regulated. As a result the enzyme Glucose-6-phosphate dehydrogenase is inhibited by NADPH and also by fatty acid esters of coenzyme A.
Glycerol is a precursor for synthesis of triacylglycerols and of phospholipids in the liver and adipose tissue. When the body uses stored fat as a source of energy, glycerol and fatty acids are released into the bloodstream. In some organisms, the glycerol component can be converted into glucose by the liver and, thus, provide energy for cellular metabolism.
Before glycerol can enter the pathway of glycolysis or gluconeogenesis (depending on physiological and environmental conditions), it must be converted to their intermediate glyceraldehyde 3-phosphate in the following steps:
Glycerol To Glycerol kinase To Glycerol-3-phosphate To Glycerol-3-phosphate dehydrogenase To Dihydroxyacetone phosphate To Triosephosphate isomerase To Glyceraldehyde 3-phosphate
Now the next step.......in understanding:
FATS STOP THE NEED FOR THE physiologic FRUCTOSE PATH...................What is this tied to? COLD and the activation of Brown fat that liberates fats!!!! Cold empties adipocytes to make the reducing elements........need for maintanence of the redox potential. This is tied to sympathetic nervous system response to cold. I spoke about this in CT 6
This means in nature...........cold and fat are a metabolic couple.......when you are a modern human you break this couple routinely and you never see efficient part of the PPP......... GOT IT?
Its all in a biochem book........but the Peat folks only read the parts they get and understand. They buy beliefs not benefits.
The fructose pathway in my view is how humans adapt from summer to autumn......these two seasons are where fructose laden foods are..............and how long they are available are tied to your location on the planet..............but this is all immaterial when you realize that our modern beliefs and beahvior allow us to constantly live outside the dictums of the photoelectric effect with respect to both food and temperature. Peat gives half truths...............the rest of the story and the part for health reversals is in the other pathway for modern humans.
Прошу прощения, что на английском, но я не могу переводить, сама читаю с переводчиком.:blush:
