усталость,перетрен и тд.

[vladimirfo]

vladimirfo, а как проявляется её нейротоксичность? Какой метаболизм? Если, конечно, уже есть ссылки на эту беду...

BRAIN CELL DAMAGE FROM AMINO ACID ISOLATES

Скрытый текст:

Following consumption of aspartame-laced products, the phenylalanine flood overpowers the enzyme systems of the brain, setting off an induced PKU effect.

This induced PKU affect occurs by grossly overwhelming those enzymes required to reduce the circulating phenylalanine for use in other metabolic reactions.

This "overdose" of the competitive phenylalanine isolate (and aspartic acid) incapacitates the enzyme actions which controls several types of neurotransmitters (and their precursor amino acids) reducing dopamine and serotonin production.

The excitotoxin's effects creates secondary components which are also destructive in nature to the sensitive, surrounding neural tissues, including a breakdown by-product of phenylalanine called, diketopiperazine (DKP) which instigates tumor generation, especially that of the aggressive glioblastoma.

Скрытый текст:

It is in the CSF, where the phenylalanine and dicarboxylic aspartic acid diffuses, setting off a chain reaction of repeated excitatory stimuli of surrounding nerve cells and neuronal structures adjacent to the flow route of the CSF. This eventually leads to nerve cell necrosis (cell death) in these areas.

Скрытый текст:

The transport of excitotoxins across the blood brain barrier and within the CSF causes several reactions to occur. 1] The excitotoxins stimulate the nerves to fire excessively. 2] The normal enzyme actions required to offset the induced, repeated firing of these neurons are negated by the phenylalanine and aspartic acid.

Furthermore, 3] the energy system for the required enzyme reactions becomes compromised from: 4] depleted intracellular ATP stores, 5] the presence of formaldehyde, 6] altered intracellular Ca+ uptake, 7] damage to cellular mitochondria, 8] destruction of the cellular wall, and 9] the subsequent release of free radicals. This potentiates 10] oxidative stress and neurodegeneration.

These toxic by-products initiate secondary damage, which increases capillary permeability, continuing to destroy the surrounding nerve and glial cells. This further impedes enzyme reactions, and 11] promotes DNA structural defects.

Но есть и обратное мнение.
"The Nature of Human Hazards Associated with Excessive Intake of Amino Acids

Скрытый текст:

In humans, the administration of a 10-g bolus dose of aspartic acid did not result in secretion of pituitary hormones (21), and administration of 75–130 mg·kg−1·d−1 aspartic acid as a supplement to an exercise regimen did not induce any reported adverse effects (22–25). In a review of the literature, the FNB noted (5) that supplements of up to 8 g/d in humans in addition to ∼3 g/d from food did not result in any documented adverse effects. Similarly, there was little evidence of toxicity in subjects given aspartic acid as aspartame (4,5).

В общем, как всегда. Кому хочешь - тому и верь.