Страница 119 из 185 ПерваяПервая ... 1969109115116117118119120121122123129169 ... ПоследняяПоследняя
Показано с 1,181 по 1,190 из 1841

Тема: Summa Technologiae

  1. #1181
    Аватар для Д.С.
    Регистрация
    24.09.2014
    Сообщений
    3,165
    Поблагодарил(а)
    16,700
    Поблагодарили 12,127 раз(а)
    Вес репутации
    135
    Telmisartan


    by Bill Roberts – Telmisartan (Micardis) is an oral prescription medication most commonly used to treat hypertension, including mild hypertension where blood pressure is only moderately elevated or borderline. If choosing to self-medicate for mild hypertension or borderline high blood pressure, telmisartan is an excellent or even best choice.


    As elevated blood pressure is often an undesired side effect of anabolic steroid cycles and can even limit use of androgens, this use of telmisartan is already enough to make the drug of value to many.


    However, telmisartan also has an entirely different category of use, due to having quite a number of other interesting properties which can be valuable in some instances.


    I don’t know of a term to describe this second category of use. The closest is a category I call “metabolic healing,” though that’s not a scientific term, in which I’ve been working to develop new administrations of natural product compounds. This has been an ongoing process I haven’t yet completed, but to me it’s extremely promising. What I mean by this category is, use of substances or combinations of substances to change gene expression in a way working to correct damages in gene expression associated with age, development of insulin resistance, and/or chronic poor diet. The goal is to return the expression (mRNA production) levels of these genes for receptors, cofactors, and cytokines to healthy values. This also is generally what telmisartan does, to a large extent, in a drug that’s already available and fairly easily obtained.


    Benefits can include improvement to fat loss, endurance, insulin sensitivity, reduction of risk of atherosclerosis, stroke, and of heart attack, and possible benefit to brain health. In some cases mood or energy can be improved as well.


    Скрытый текст:
    When to use telmisartan


    If blood pressure needs to be moderated, I’d certainly consider using telmisartan. If there is no such need, factors that could suggest its use include interest in reducing visceral fat, of improving impaired insulin sensitivity, of reducing risk of atherosclerosis, or depending on personal interest, of possibly improving brain health and function.


    Reasons not to use telmisartan could include unwillingness to accept the risk of possible side effects, or unwillingness to shift the balance of fat loss towards visceral fat loss versus subcutaneous fat loss. In general, if dieting and training achieve only the same bodyfat percentage despite the positive effects of telmisartan, appearance could be smoother due to the same amount of bodyfat being present but with less of it stored as unhealthful visceral fat. On the other hand, if taking advantage of improved loss of visceral fat with telmisartan to achieve a lower bodyfat percentage, then there’s no smoothness penalty. However, when aiming for contest condition there’s a certain amount of fat that the body must retain: theoretically, reducing visceral fat in this case might force retention of a greater amount of subcutaneous fat. So I wouldn’t advise telmisartan use in the last few weeks before a bodybuilding contest.


    How to use telmisartan


    To reduce risk of atherosclerosis, cardiovascular disease, or stroke where risk is only moderate in the first place, I suggest a dose from 20 to 40 mg taken orally once per day. Dosing would be the same where the interest is slowing loss of brain function with age, or potentially improving brain function.


    For possible improvement in fat loss, particularly of visceral fat, or improvement of endurance I suggest dosing of 80-160 mg/day. Starting dose, however, generally should be only 40 mg/day until tolerance is assessed.


    While it’s not required and telmisartan users in general do not do so, when using this drug I suggest supplementing with oleuropein 200-400 mg/day and Vitamin D 5000 IU/day. These are to reduce or perhaps eliminate two activities of telmisartan that I would not consider desirable for physique or performance enhancement, though they add to its medical use.


    Telmisartan should not be used in combination with a diuretic, and I would avoid allowing severe dehydration while using this drug.


    Blood pressure should be monitored while using telmisartan. Typically, any decrease of blood pressure is simply to healthful levels or more-nearly healthful levels, and those who do not have high blood pressure see no decrease with telmisartan. Still, there can be exceptions, so this should be watched.


    Lastly, I would cycle telmisartan use rather than use it continuously. There’s no proof of what cycling method might be optimal, but for example I’d suggest being “off” about as many weeks per year as “on” as a minimum. This is not because of proven problem, but simply because I expect the benefits can be fully or nearly fully realized with this amount of use, and where any of the changes to gene expression or receptor blocking might be adverse in the individual case rather than beneficial, this will then be no more than half the time.


    Pharmacological effects of telmisartan


    Briefly, telmisartan is in the pharmacological class of angiotensin receptor blocker, but has many effects on gene expression which generally are favorable to metabolism, endurance, and body composition. Results can include increasing PPAR-delta, GLUT4, UCP1, SIRT1, AMPK, HDL, phospho-AMPK-α, hormone lipase, adiponectin, leptin, CRP, IL-1β, and fatty acid oxidation in muscle; decreasing aldosterone, TNFα, LDL, serum triglycerides, inflammation in adipose tissue, and fasting blood glucose; and inhibiting adipogenesis.


    All these can be helpful activities for fat loss or for improved health; PPAR-delta activation also can result in increased muscle endurance via increasing oxidative capacity of Type II fibers.


    Telmisartan also is a partial agonist of PPAR-gamma, which while useful for those with diabetes, I would not choose for a physique-enhancing drug because activating PPAR-gamma works towards enhancing fat storage. Telmisartan has so many activities working against fat storage that overall it’s unlikely to gain bodyfat from the PPAR-gamma mechanism, but still I would prefer to minimize this activation. Oleuropein supplementation can work towards blocking this activation, so it’s a suggested supplement to use in combination with telmisartan.


    The other undesired activity is partial blocking of the 1,25-dihydroxyvitamin-D receptor. I would address this with supplementation of Vitamin D.


    Muscle fiber type switching?


    Telmisartan has a biochemical effect on muscle cells which is very similar to the effect of exercise. A consequence of this is increased oxidative capacity of Type II muscle fibers, which may be called “switching” from Type IIb to Type IIa. It’s possible that such switching could be a significant concern for powerlifters, Olympic lifters, shotputters, or other extremely explosive athletes. On the other hand, ordinary resistance training also induces the same effect, and any such effect is likely reversible in any case.


    Switching between Type II and Type I fibers, which would be of more concern, does not happen with telmisartan so far as is known. (Such switching in humans appears possible only by changing the nerve to which the muscle fiber is connected.


    In general, it’s not necessary to be concerned that telmisartan use will result in a bodybuilder-type physique becoming an endurance athlete-type physique. But increased ability to do high rep work is common.


    Telmisartan and left ventricle hypertrophy


    There’s no human evidence as yet as to whether telmisartan use may reverse or partially reverse anabolic steroid induced left ventricle hypertrophy (LVH), but in animal models telmisartan can act to reverse LVH. Time will tell whether reversal or partial reversal of anabolic steroid-induced LVH might be yet another benefit of telmisartan use.


    Possible side effects of telmisartan


    While telmisartan is generally well-tolerated, potential side effects include headache, dizziness, diarrhea, tiredness, and similar complaints though these are relatively uncommon. Serious side effects of rhabdomyolysis and angioedema are known but very rare. Allergic response is possible. Discontinue telmisartan use if experiencing serious side effects.


    A fuller listing of potential side effects may be found here. It should be kept in mind that nearly every side effect mentioned is also reported by the placebo group, and generally with similar frequency.


    Conclusion


    Telmisartan can be useful for moderating blood pressure of those with elevated blood pressure, both when using anabolic steroids and when not doing so, and also can improve endurance, aid fat loss, and potentially may improve long term health.



  2. #1182
    Аватар для Д.С.
    Регистрация
    24.09.2014
    Сообщений
    3,165
    Поблагодарил(а)
    16,700
    Поблагодарили 12,127 раз(а)
    Вес репутации
    135
    Пептиды. Советские разработки.
    Рекомендации по конкретному использованию.


    Peptide Bioregulators, gene switches that could replace stem cells!



    This former Russian military secret is now available to the public!

    Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.

    Скрытый текст:
    What their secret research uncovered - that was used for two decades on many thousands of men and women - was a remarkable link between short chain peptides and DNA.

    Now their published research is in the open and it identifies that each organ / gland / tissue uses a highly specific short chain peptide to act as a ‘short cut’ to initiate protein synthesis. These peptides can be found in food and unlike proteins they can enter the blood through the stomach. Through a comprehensive list of patents and even copyrighted PowerPoint slides, the Russian research group are showing that each of the concentrated peptide bioregulators so far examined interact with particular strands of DNA - effectively and very specifically activating repair and regenerative processes.

    This is a remarkable story since what we are describing here are individualised gene switches and since they have been tested for many years on thousands of individuals, without report of any serious side effects or contraindications to date, they could be set to ‘out do’ stem cells. Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully.

    Professor Khavinson and his award winning team at the St Petersburg Institute of Biogerontology have discovered that each organ / gland has a biological reserve and despite the origin of the tissue they have studied, incredibly each one is always set at 42%

    Even dosing doesn’t need to be daily, these peptide bioregulators have been shown to act even after a simple course of 2 capsules daily for 10-days. Healthy individuals only being encouraged to repeat the course 6-months later, although of course depending on the need this course can be repeated every 3-months, 2-months or 1-month if necessary. But compared to a hormone replacement therapy this is interesting, since hormones would require almost daily application. But these peptide bioregulators aren’t hormones, they are acting on the gland concerned to ‘encourage’ it to become active and effectively ‘younger’ by triggering / activating the DNA responsible.

    Here at IAS we are excited about this emerging technology and have been following it since 2010 and will be reporting much more, though articles, interviews and videos etc., so please stay tuned. There’s more to learn including the synergistic interaction of the peptide bioregulators themselves and if individuals are using hormones concurrently, then there may well be a need to monitor their blood levels more closely with a view to lowering those doses and applications etc.

    Note: Of the 20 or so peptide bioregulators available IAS has chosen the following, (and will be adding more into the range in due course). All the sources of these Peptide Bioregulators are from carefully chosen Danish bovine tissues and processed through pharmaceutical processes and filters.

    Currently all of these peptide regulator capsules enjoy registration on the Russian market as food supplements.

    What can you expect from the peptide bioregulators?

    Cerluten® is the brain peptide bioregulator.
    Chelohart® is the heart peptide bioregulator.
    Chitomur® is the bladder peptide bioregulator.
    Endoluten® is the pineal peptide bioregulator.
    Glandokort® is the adrenal peptide bioregulator.
    Gotratix® is the muscle peptide bioregulator.
    Libidon® is the prostate gland peptide bioregulator.
    Pielotax® is the kidney peptide bioregulator.
    Sigumir® is the cartilage peptide bioregulator.
    Suprefort® is the pancreas peptide bioregulator.
    Stamakort® is the stomach mucus peptide bioregulator.
    Svetinorm® is the liver peptide bioregulator.
    Taxorest® is the lung peptide bioregulator.
    Testoluten® is the testes peptide bioregulator.
    Thyreogen® is the thyroid peptide bioregulator.
    Ventfort® is the blood vessel peptide bioregulator.
    Visoluten® is the retina peptide bioregulator.
    Vladonix® is the thymus peptide bioregulator.
    Zhenoluten® is the ovary peptide bioregulator.
    IAS is the first western organisation to make these peptide bioregulators available and we shall be reporting regularly on them.
    Frequently Asked Questions About PEPTIDE BIOREGULATORS

    Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical / published results.
    Q. Which PB is best for blood pressure?

    A. Ventfort® -start at 2-capsules daily for 30-days, repeat at 2 capsules daily for 10-days each month. As the condition improves the 10-day cycle can be reduced to every 2, 3 or even 4 months. Don’t overlook the possibility that low levels of magnesium could be involved.

    Q. Which PB is best for atrial fibrillation?

    A. Chelohart®- start at 2-capsules daily for 30-days, repeat at 2 capsules daily for 10-days each month. As the condition improves the 10-day cycle can be reduced to every 2, 3 or even 4 months. Note: Don’t overlook the possibility that low levels of progesterone and/ or magnesium could be involved.

    Q. What does the muscle peptide Gotratix® do?

    A. The Gotratix® peptide regulates the metabolism processes in muscular cells, improves their safety margin and has a favorable effect on adaptive capabilities in extreme conditions; it also has antioxidant properties and helps to regulate the peroxidation processes in the muscular tissues. Thus, it can be expected that Gotratix® is an effective means to restore the function of muscles under intense physical load, like those involved in sports.
    It is commonly known that various means and methods of pharmacological and more recent genetic correction, can be used to improve the physical performance capability of athletes and their adaptation to increased physical and psycho-emotional loads, (Seyfulla, 1999; Yakimov, 2001). Irrefutably evident is the fact, that athletes using banned pharmaceutical products, cannot maintain stable high competition for a long time, because they have physiological failures at the high loads, (Semenov et al., 2002). The risk is made worse because of many new stimulators, whose doping effect is disguised by different food and vitamin additives, (Mikhailov, 2006).
    Therefore this is not only an issue of the early detection of the negative consequences of administration of modern doping substances, but also the need to develop methods for the bioregulation of physiological reserves for high-qualification athletes; to help create effective prevention of physical de-adaptation in their training cycles.

    Furthermore, maintaining the spare capacity of the muscular system is also a problem for people who do moderate physical exercise and especially for older individuals who may be developing sarcopenia.
    A clinical study of Gotratix® peptide efficiency was carried out at the Medical center of Saint Petersburg Institute of Bioregulation and Gerontology between April till November 2011. The study included 37 veterans of sport aged between 40 and 65 years, including 19 men and 8 women who specialized in rowing and track-and-field athletics. Those examined in the control group (17 persons), had been training under a general program. Athletes in the treated group (20 persons), in addition to basic training also took Gotratix® at 2 capsules twice daily (at mealtimes) for 30 days.

    It was established that the application of Gotratix® resulted in the improvement of the general condition of the patients in the treated group over the controls. All treated patients noticed an increase in their physical efficiency. The parameters of speed and force for dynamometry and standing long-jump were significantly higher in the treated group when compared to the controls. Step-test and dorsal spine mobility parameters in the persons examined, taking Gotratix®, were also improved over the controls.

    Q. Does it make sense to take the Thyreogen® peptide if my thyroid has been removed completely and subsequently I'm taking 240 mgs of Armour thyroid? I wasn't sure if it was pointless if I have no thyroid.
    A. You are correct that in this instance it would be pointless. The peptide bioregulators work by initiating the ‘biological reserve’ of the gland/ organ in question. If that gland has been removed nothing can be initiated, therefore as you are currently doing the only way to address such a situation is to take the relevant hormone.

    Q. I need to provide a peptide bioregulator for someone that had a heart attack and with CHF. I wanted to know what is your opinion?

    A. Professor Khavinson’s recommends the following peptide bioregulators for their synergy:

    Heart peptide (Chelokhart®)
    Blood vessel peptide (Ventfort®)
    Liver peptide (Svetinorm®)

    The intensive course is 2 (QD or BID) capsules daily for 30-days, thereafter 2 capsules QD for 10-days each month.

    It is worth noting that the published work of cardiologist Kenneth Kensey suggests that the two most important criteria to assess risk of heart attack (or stroke) are blood viscosity and arterial stiffness. Another recent publication even suggested that Alzheimer’s may be due to viscous blood too! So an answer is to keep arteries ‘soft’ and blood ‘thin.’

    Published in December 2013 in the Journal of Aging Science are supplements that can reverse arterial stiffness. The fastest to work are those that can release nitric-oxide, L-arginine and L-citrulline, (Nitric-Pro® powder and Neo40® lozenges respectively- nitric-oxide levels can be tested with Neo40® saliva test strips.) Plus anything that acts as an anti-glycation agent is excellent also, this could be metformin, aminoguanidine or L-carnosine.
    To ‘thin’ blood supplements with resveratrol can assist, as can the enzymes in Boluoke® and Wobenzym®. A child’s aspirin is the ‘classic’ approach, but its long term use can damage the stomach lining.

    For additional protection, choose Bio En-R’Gy C® (a vitamin C drink that also contains ribose which is excellent to maintain pulse and MSM to reduce inflammation) and CoQ10 in high doses should also be considered, (or idebenone in lower doses).

    I am interested in about 7 of them for different concerns. For example I would like to try the 3 recommended for vision, as well as adrenal, thymus, pineal, and maybe cartilage. Is it possible to take 3 for 10 days, then the other 3 or 4 the next 10 days of the month? Or should you alternate months taking 3 or 4 each month?

    There is no problem with combining them all at the same time. This is because each has a highly specific gene reaction that is only applicable to that gland or organ. Of course in some cases the improvement of particular hormones could interfere with each other and this should be noted and monitored.

    The best beginning is to know one’s weak points and address them first. That can also give a target for dosing, i.e. to dose the weak points more aggressively and the others less so.
    As you may remember from the Aging Matters™ article, general support can be as little as 2-capsules a day for 10-days (that’s one package) followed up again in 6-months. Dependent upon the need the follow up could be each 4, 3 or 2 months.

    An aggressive dosing schedule is 1 or 2 capsules twice daily for 30-days.

    How should a 70 year old lady with Multiple Sclerosis be treated?

    A difficult case but you can try Cerluten® - nervous system peptide, Endoluten® - pineal peptide, and Ventfort® - blood vessel peptide. You can combine them for example in the following way: 1 capsule of each in the morning and 1 capsule of each again in the evening for at least 30 days; repeated as necessary.

    How should a 67-year old post-menopausal woman who has chronic insomnia be treated?
    Try Endoluten® - pineal peptide - 2 capsules daily for 1-month, repeated as necessary. This will improve melatonin secretion.

    How should a 68 year old man with chronic fatigue with sleep problems be treated?
    Try Endoluten® - pineal peptide - 2 capsules daily for 1 month but this may require regular repeat dosing.

    How should an insulin dependent diabetic be treated?
    Difficult if there is a strong insulin dependency, try Suprefort® - pancreas peptide - and Endoluten® - pineal peptide.

    How should a type 2 diabetic or a person with metabolic syndrome/insulin resistance be treated?
    Combine Suprefort® -pancreas peptide - and Endoluten® - pineal peptide

    What combination of peptides would be best to consider for the elderly in general?
    Glandokort® - adrenal peptide, Vladonix® -thymus peptide and Ventfort® - blood vessels peptide.

    Would there be a difference between dosing for men and women?
    Not particularly, the dosing is more related to need than sex or bodyweight

    Is it best to include the blood vessel peptide in all combinations used?
    Yes it is recommended, the blood vessel peptide is known as Ventfort®

    What peptides would be recommended for a menopausal lady with osteoporosis?
    Sigumir® is the cartilage peptide but will be required with regular repeats

    How to correct disorders of the immune system?
    Combine Vladonix® - thymus peptide, Endoluten® - pineal peptide and Ventfort® -blood vessel peptide

    How to correct disorders of the thyroid?
    Combine Thyreogen® - thyroid peptide and Ventfort® - blood vessel peptide

    How to correct disorders of the kidneys?
    Combine Pielotax® - kidney peptide and Ventfort® - blood vessel peptide

    How to correct disorders of the testes?
    Combine Testoluten® and Ventfort® - blood vessel peptide

    How to correct disorders of the prostate?
    Combine Libidon® - prostate peptide and Ventfort® -blood vessel peptide

    How to correct disorders of the retina?
    Combine Visoluten® - retina peptide and Ventfort® - blood vessel peptide

    How to correct eyesight problems in general?
    Combine Visoluten® -r etina peptide, Ventfort® - blood vessel peptide and Cerluten® - brain peptide

    How to correct disorders of the liver?
    Combine Svetinorm® - liver peptide and Ventfort® - blood vessel peptide

    How to correct disorders related to the central nervous system?
    Combine Cerluten® - brain peptide and Ventfort® - blood vessel peptide

    How to correct disorders related to the adrenal glands?
    Combine Glandokort® - adrenal peptide and Ventfort® - blood vessel peptide

    What is the typical dosing regimen for the peptides in general?
    Two capsules a day for 10-days - a total of 20 capsules equivalent to one pack - for general support this can be repeated again in 6-months’ time, if the need is greater then it can be repeated again in 2 to 3 months’ time, if the need is felt to be great then typically the regimen is repeated every month.

    Q. This is a case of neovascular retinal overgrowth treated with laser ablation. Now there is a central blind spot where the laser also destroyed the retinal cells.
    As a rule apply a complex of peptides - retinal peptide (Visoluten®), peptide from the brain (Cerluten®), immune peptide (Thyreogen®), peptide from vessels (Ventfort®); in order to reduce macular edema and to reduce vascularization.

    Q. Spinal stenosis treated with Spinal fusion and finally Laminectomy. Now still has peripheral nerve symptoms including muscle pain and weakness.
    In case of spondylarthrosis we apply a course of peptide preparations from cartilages (Sigumir®), nervous system (Cerluten®) and vessels (Ventfort®).


    https://www.antiaging-systems.com/25...-bioregulators

  3. 1 пользователь сказал cпасибо Д.С. за это полезное сообщение::

    alabaychic (29.08.2016)

  4. #1183
    Аватар для NAFL
    Регистрация
    27.09.2014
    Сообщений
    712
    Поблагодарил(а)
    4,439
    Поблагодарили 2,335 раз(а)
    Вес репутации
    34
    Нмного размышлений про оксидативный стресс.
    ЛПВП - строительный материал для клеток.
    ЛПНП(плохой холестерин) - топливо. В экспериментах у Минвалиева (дыхательные техники, туммо) ЛПНП в крови снижаются. Избыток холестерина в крови приводит к перфорированию мембран митохондрий и ухудшению производства ими АТФ. А в дальнейшем и к гибели, что ведет за собой и гибель клетки.
    Крысы или мыши которые сидели на ограниченном пайке живут дольше, но достаточно мелкие. Можно предположить, что ограниченный паек не приводит к увеличению ЛПНП в крови и как следствие к перикисному окислению жиров и укорочение теломеров не такое быстрое.
    Есть еще одно предположение. Холестерин в крови регулируется по некоему индивидуальному эталону % жира. Пузо+гормоны представляют собой некий буфер защищающий от переизбытка холестерина в крови. Если привести % жира к оптимуму, или чуть ниже, то адипоциты будут легче забирать избыток ЖК из крови.
    Как некий итог. Чем больше митохондрий, тем их колония в клетке более живучая. Если строить свое питание и активность так, чтобы ЛПНП в период бездействия в крови было по минимуму, то специальные антиоксиданты не нужны. или проще говоря - перед активностью поел, а вот после не факт, что нужно. Перед сном не жрать, а аэробная прогулка + можно немного дыхательных техник.

  5. 2 пользователей сказали cпасибо NAFL за это полезное сообщение:

    winner (30.08.2016), Д.С. (29.08.2016)

  6. #1184
    Аватар для Миклухо Маклаев
    Регистрация
    29.07.2014
    Адрес
    Кузбасс
    Сообщений
    12,921
    Поблагодарил(а)
    30,466
    Поблагодарили 39,339 раз(а)
    Вес репутации
    416
    на канале наука 2.0 сейчас передачка идет о том как победить грусть.
    в общем спортсмены очень редко испытывают депрессию по сравнению с людьми без физ нагрузок.
    Скрытый текст:
    Бокс совершенно не оказывает негативного влияния на здоровье. (с) Boss



    только пока человек борется со своими слабостями, он остается человеком.

  7. 5 пользователей сказали cпасибо Миклухо Маклаев за это полезное сообщение:

    alabaychic (29.08.2016), NAFL (29.08.2016), vladimirfo (29.08.2016), winner (30.08.2016), Д.С. (29.08.2016)

  8. #1185
    Аватар для vladimirfo
    Регистрация
    03.10.2014
    Адрес
    Москва
    Сообщений
    2,311
    Поблагодарил(а)
    2,584
    Поблагодарили 7,490 раз(а)
    Вес репутации
    88
    Догма о вреде LDL и холестерина в целом уже разбита в пух и прах.
    У половины первых инфарктников холестерин в норме.
    Если нормального уровня LDL не будет хватать для синтеза гормонов и их функции, для борьбы с воспалением, то уже надо думать почему так.
    Диета с кучей молочки иногда дает высокий LDL, генетические нарушения - тоже.
    У японцев низкий уровень ССЗ, и завышенные уровни холестерина в крови.
    Естественно, что туммо и закаливание будут снижать уровень общего воспаления.
    Также и % жира в норме говорит об отсутствии серьезных воспалительных процессов. И что организму не надо усиливать выработку LDL.
    Мое скромное мнение, что этот индивидуальный эталон - уровень различных воспалительных процессов, на который организм вынужден реагировать.

  9. 4 пользователей сказали cпасибо vladimirfo за это полезное сообщение:

    deadok (29.08.2016), Миклухо Маклаев (29.08.2016), winner (30.08.2016), Д.С. (29.08.2016)

  10. #1186
    Аватар для vladimirfo
    Регистрация
    03.10.2014
    Адрес
    Москва
    Сообщений
    2,311
    Поблагодарил(а)
    2,584
    Поблагодарили 7,490 раз(а)
    Вес репутации
    88
    New mechanisms of metformin action: Focusing on mitochondria and the gut
    Бомбическая сатья про действие метформина.
    Кроме того, что он ингибирует комплекс 1 митохондрий (ранее считалось основным механизмом):
    - в основном он работает в кишечнике, улучшая усвоение глюкозы (основные побочки именно с ЖКТ); - там же его наибольшая концентрация.
    - ингибирует глюконеогенез из глицерина (жиров);
    - отдельно интересно исследование, где мыши с годной микрофлорой кишечника не полнели при плохой диете;
    - высокожировая диета и метформин улучшали микрофлору кишечника и улучшали метаболический профиль мышей;
    - результаты с увеличением продолжительности жизни мышей и червей тоже связаны с микрофлорой кишечника - метформин менял метаболизм фолатов и метилметеонина, имитируя эффект дефецита калорий;
    - улучшает сигнальную функцию и эксррессию рертида GLP-1 поджелудочной - то есть да, способен улучшать функцию поджелудочной по части чувствительности к инсулину;
    Итд

    Веществу почти 100 лет, первая фарм-компания, которая произвела метформиновый препарат, празднует 50 лет препарату. А к сути вопроса только подобрались.

  11. 5 пользователей сказали cпасибо vladimirfo за это полезное сообщение:

    alabaychic (29.08.2016), Carceri (29.08.2016), Миклухо Маклаев (29.08.2016), NAFL (29.08.2016), Д.С. (29.08.2016)

  12. #1187
    Аватар для vladimirfo
    Регистрация
    03.10.2014
    Адрес
    Москва
    Сообщений
    2,311
    Поблагодарил(а)
    2,584
    Поблагодарили 7,490 раз(а)
    Вес репутации
    88
    LDL / ЛПНП
    Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. - PubMed - NCBI - люди с высоким LDL ("плохим" холестерином) живут дольше людей с низким LDL.

    Циркадные часы
    https://www.chronobiology.com/gut-mi...y-play-a-role/ - у кишечных бактерий они тоже есть; хотя в статье освещен только мелатониновый аспект;
    Основной вывод - режим влияет на здоровье и кишечника тоже.
    Circadian Clocks in Articular Cartilage and Bone - циркадные часы в хрящах/костях.
    Sci-Hub: removing barriers in the way of science - полную версию можно прочитать через Sci-Hub.
    Если коротко говорить подводку из Abstracta, то суставные хрящи при травмах не обладают большими эндогенными возможностями для восстановления. Потому гомеостаз наших суставов/костей (как организму это удается) - интересная тема.
    Ответ - циркадные ритмы (всего организма и отдельных тканей).

  13. 1 пользователь сказал cпасибо vladimirfo за это полезное сообщение::

    Д.С. (31.08.2016)

  14. #1188
    Аватар для vladimirfo
    Регистрация
    03.10.2014
    Адрес
    Москва
    Сообщений
    2,311
    Поблагодарил(а)
    2,584
    Поблагодарили 7,490 раз(а)
    Вес репутации
    88
    Klebsiella: The Cause of Rheumatoid Arthritis and Alkalizing Spondylitis, Part 2
    Джон Бриссон поднимает тему роли бактерий клебсиелла в ревматоидном артрите и болезни Бехтерева.

    Расплод этой бактерии может приводить к мутации в HLAB-27 гене (как у меня).
    Мутации в этом гене приводит к некорректному ответу иммунной системы на расплод клебсиеллы, что позволяет бактерии плодиться еще яростней.
    Эндотоксины из этой бактерии приводят к большому количеству Th1 (иммунные Т-хелперы, клетки, которые борются с грамотрицальными бактериями).

    Удивительно, что причина болезни Бехтерева (чуть не получил это диагноз года 3-4 назад) может быть не только генетической, но эпигенетической + бактериальной.

    И еще один факт в пользу того, что без здорового кишечника хорошо работающей иммунной системы не будет.

  15. 3 пользователей сказали cпасибо vladimirfo за это полезное сообщение:

    alabaychic (01.09.2016), NAFL (01.09.2016), Д.С. (31.08.2016)

  16. #1189
    Аватар для Д.С.
    Регистрация
    24.09.2014
    Сообщений
    3,165
    Поблагодарил(а)
    16,700
    Поблагодарили 12,127 раз(а)
    Вес репутации
    135
    Три генетики (ядерная ДНК, ДНК митохондрий и бактерии кишечника) в продолжительности жизни человека, если его рассматривать как метаорганизм. 2014 год.

    The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

    Abstract

    Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and number of genes encoded, plays a major role in the ageing process. The complex interplay between nDNA/mtDNA and the environment is most likely involved in phenomena such as ageing and longevity. To this scenario we have to add another level of complexity represented by the microbiota, that is, the whole set of bacteria present in the different part of our body with their whole set of genes. In particular, several studies investigated the role of gut microbiota (GM) modifications in ageing and longevity and an age-related GM signature was found. In this view, human being must be considered as “metaorganism” and a more holistic approach is necessary to grasp the complex dynamics of the interaction between the environment and nDNA-mtDNA-GM of the host during ageing. In this review, the relationship between the three genetics and human longevity is addressed to point out that a comprehensive view will allow the researchers to properly address the complex interactions that occur during human lifespan.

  17. 1 пользователь сказал cпасибо Д.С. за это полезное сообщение::

    vladimirfo (31.08.2016)

  18. #1190
    Аватар для vladimirfo
    Регистрация
    03.10.2014
    Адрес
    Москва
    Сообщений
    2,311
    Поблагодарил(а)
    2,584
    Поблагодарили 7,490 раз(а)
    Вес репутации
    88
    USF :: Department of Psychology
    Статья о статинах.
    Там есть красивая фраза:"Вероятно сложно принять ложность утверждения, что холестерин приводит к ССЗ".
    По сути на 1% успешных случаев применения статинов есть 5% случаев нежелательных эффектов, пятикратный шанс получить диабет 2го типа и прочие радости. А данными результатов можно манипулировать, получая 20-50%
    Но именно статины и их побочки запустили волну исследований про LDL и про "необходимость" с ним бороться.

    Но ссания на фарм-компании я не понимаю. Это может говорить только тот, кто с фармой не работал.
    До одобрения лекарство проходит исследования на тысячах людей и едят их потом миллионы. Иногда конечный эффект не всегда совпадает с предполагаемым (виагра проходила испытания как лекарство от давления), иногда далеко не все побочные явления мы можем сразу увидеть, иногда лекарство применяют не по показаниям в инструкции (тот же метформин для похудания).
    И если ты связан с какой-то программой (активностью) фарм-компании, где люди могут сообщить о нежелательных эффектах, то все сотрудники проходят обучение по фармаконадзору, сдают тесты.
    Потенциальное сообщение о нежелательных явлениях должно быть сообщено в глобальный фармаковиджеленс в течение суток!
    Московский офис американо-европейской компании может проверить не только фармаконадзор, но и FDA и аналогичный надзорный европейский орган.
    И у комплаенс в фармнадзоре может быть 100% или провальный.

  19. 2 пользователей сказали cпасибо vladimirfo за это полезное сообщение:

    Carceri (01.09.2016), Д.С. (01.09.2016)

Социальные закладки

Социальные закладки

Ваши права

  • Вы не можете создавать новые темы
  • Вы не можете отвечать в темах
  • Вы не можете прикреплять вложения
  • Вы не можете редактировать свои сообщения
  •